2022

Shapira T, Monreal IA, Dion SP, Buchholz DW, Imbiakha B, Olmstead AD, Jager M, Désilets A, Gao G, Martins M, Vandal T, Thompson CAH, Chin A, Rees WD, Steiner T, Nabi IR, Marsault E, Sahler J, Diel DG, Van de Walle GR, August A, Whittaker GR, Boudreault PL, Leduc R, Aguilar HC, Jean F. A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic. Nature. 2022 Mar 28. doi: 10.1038/s41586-022-04661-w. Epub ahead of print. PMID: 35344983.

Martins M, Boggiatto PM, Buckley A, Cassmann ED, Falkenberg S, Caserta LC, Fernandes MHV, Kanipe C, Lager K, Palmer MV, Diel DG. From Deer-to-Deer: SARS-CoV-2 is efficiently transmitted and presents broad tissue tropism and replication sites in white-tailed deer. PLoS Pathog. 2022 Mar 21;18(3):e1010197. doi: 10.1371/journal.ppat.1010197. PMID: 35312736; PMCID: PMC8970504.

Turbinate

Guarino C, Larson E, Babasyan S, Rollins A, Joshi LR, Laverack M, Parrilla L, Plocharczyk E, Diel DG, Wagner B. Development of a quantitative COVID-19 multiplex assay and its use for serological surveillance in a low SARS-CoV-2 incidence community. PLoS One. 2022 Jan 21;17(1):e0262868. doi: 10.1371/journal.pone.0262868. PMID: 35061843; PMCID: PMC8782306.

Lubinski B, Fernandes MHV, Frazier L, Tang T, Daniel S, Diel DG, Jaimes JA, Whittaker GR. Functional evaluation of the P681H mutation on the proteolytic activation of the SARS-CoV-2 variant B.1.1.7 (Alpha) spike. iScience. 2022 Jan 21;25(1):103589. doi: 10.1016/j.isci.2021.103589. Epub 2021 Dec 10. PMID: 34909610; PMCID: PMC8662955.

Martins M, Fernandes MHV, Joshi LR, Diel DG. Age-Related Susceptibility of Ferrets to SARS-CoV-2 Infection. J Virol. 2022 Feb 9;96(3):e0145521. doi: 10.1128/JVI.01455-21. Epub 2021 Nov 24. PMID: 34817200; PMCID: PMC8826803.

Figure-JVI01455-21

2021

Anderson TK, Inderski B, Diel DG, Hause BM, Porter EG, Clement T, Nelson EA, Bai J, Christopher-Hennings J, Gauger PC, Zhang J, Harmon KM, Main R, Lager KM, Faaberg KS. The United States Swine Pathogen Database: integrating veterinary diagnostic laboratory sequence data to monitor emerging pathogens of swine. Database (Oxford). 2021 Dec 15;2021:baab078. doi: 10.1093/database/baab078. PMID: 35165687; PMCID: PMC8903347.

Mitchell PK, Martins M, Reilly T, Caserta LC, Anderson RR, Cronk BD, Murphy J, Goodrich EL, Diel DG. SARS-CoV-2 B.1.1.7 Variant Infection in Malayan Tigers, Virginia, USA. Emerg Infect Dis. 2021 Dec;27(12):3171-3173. doi: 10.3201/eid2712.211234. PMID: 34808082; PMCID: PMC8632162.

Carpenter A, Ghai RR, Gary J, Ritter JM, Carvallo FR, Diel DG, Martins M, Murphy J, Schroeder B, Brightbill K, Tewari D, Boger L, Gabel J, Cobb R, Hennebelle J, Stanton JB, McCullough K, Mosley YC, Naikare HK, Radcliffe R, Parr B, Balsamo G, Robbins B, Smith D, Slavinski S, Williams C, Meckes D, Jones D, Frazier T, Steury K, Rooney J, Torchetti M, Wendling N, Currie D, Behravesh CB, Wallace RM. Determining the role of natural SARS-CoV-2 infection in the death of domestic pets: 10 cases (2020-2021). J Am Vet Med Assoc. 2021 Nov 1;259(9):1032-1039. doi: 10.2460/javma.259.9.1032. PMID: 34647475.

Marcano VC, Cardenas-Garcia S, Diel DG, Antoniassi da Silva LH, Gogal RM Jr, Miller PJ, Brown CC, Butt SL, Goraichuk IV, Dimitrov KM, Taylor TL, Williams-Coplin D, Olivier TL, Stanton JB, Afonso CL. A Novel Recombinant Newcastle Disease Vaccine Improves Post- In Ovo Vaccination Survival with Sustained Protection against Virulent Challenge. Vaccines (Basel). 2021 Aug 26;9(9):953. doi: 10.3390/vaccines9090953. PMID: 34579191; PMCID: PMC8472951.

C Caserta L, G Noll JC, Singrey A, Niederwerder MC, Dee S, Nelson EA, Diel DG. Stability of Senecavirus A in animal feed ingredients and infection following consumption of contaminated feed. Transbound Emerg Dis. 2022 Jan;69(1):88-96. doi: 10.1111/tbed.14310. Epub 2021 Sep 25. PMID: 34473909.

Carvallo FR, Martins M, Joshi LR, Caserta LC, Mitchell PK, Cecere T, Hancock S, Goodrich EL, Murphy J, Diel DG. Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy. Viruses. 2021 Jul 31;13(8):1510. doi: 10.3390/v13081510. PMID: 34452375; PMCID: PMC8402861.

Fig. 3

Buckley A, Falkenberg S, Martins M, Laverack M, Palmer MV, Lager K, Diel DG. Intravenous, Intratracheal, and Intranasal Inoculation of Swine with SARS-CoV-2. Viruses. 2021 Jul 30;13(8):1506. doi: 10.3390/v13081506. PMID: 34452371; PMCID: PMC8402769.

Joshi LR, Knudsen D, Piñeyro P, Dhakal S, Renukaradhya GJ, Diel DG. Protective Efficacy of an Orf Virus-Vector Encoding the Hemagglutinin and the Nucleoprotein of Influenza A Virus in Swine. Front Immunol. 2021 Nov 5;12:747574. doi: 10.3389/fimmu.2021.747574. PMID: 34804030; PMCID: PMC8602839.

ORFV-SIV

Gomes Noll JC, do Nascimento GM, Diel DG. Natural Transmission and Experimental Models of SARS CoV-2 Infection in Animals. Comp Med. 2021 Oct 1;71(5):369-382. doi: 10.30802/AALAS-CM-21-000046. Epub 2021 Oct 26. PMID: 34702427; PMCID: PMC8594260.

animal-comp

Carpenter A, Ghai RR, Gary J, Ritter JM, Carvallo FR, Diel DG, Martins M, Murphy J, Schroeder B, Brightbill K, Tewari D, Boger L, Gabel J, Cobb R, Hennebelle J, Stanton JB, McCullough K, Mosley YC, Naikare HK, Radcliffe R, Parr B, Balsamo G, Robbins B, Smith D, Slavinski S, Williams C, Meckes D, Jones D, Frazier T, Steury K, Rooney J, Torchetti M, Wendling N, Currie D, Behravesh CB, Wallace RM. Determining the role of natural SARS-CoV-2 infection in the death of domestic pets: 10 cases (2020-2021). J Am Vet Med Assoc. 2021 Nov 1;259(9):1032-1039. doi: 10.2460/javma.259.9.1032. PMID: 34647475.

Marcano VC, Cardenas-Garcia S, Diel DG, Antoniassi da Silva LH, Gogal RM Jr, Miller PJ, Brown CC, Butt SL, Goraichuk IV, Dimitrov KM, Taylor TL, Williams-Coplin D, Olivier TL, Stanton JB, Afonso CL. A Novel Recombinant Newcastle Disease Vaccine Improves Post- In Ovo Vaccination Survival with Sustained Protection against Virulent Challenge. Vaccines (Basel). 2021 Aug 26;9(9):953. doi: 10.3390/vaccines9090953. PMID: 34579191; PMCID: PMC8472951.

Fernandes MHV, de Lima M, Joshi LR, Diel DG. A virulent and pathogenic infectious clone of Senecavirus A. J Gen Virol. 2021 Aug;102(8):001643. doi: 10.1099/jgv.0.001643. PMID: 34424160; PMCID: PMC8489587.

rSVA-iClone

Marcano VC, Susta L, Diel DG, Cardenas-Garcia S, Miller PJ, Afonso CL, Brown CC. Evaluation of chickens infected with a recombinant virulent NDV clone expressing chicken IL4. Microb Pathog. 2021 Oct;159:105116. doi: 10.1016/j.micpath.2021.105116. Epub 2021 Jul 31. PMID: 34339794.

Paim WP, Bauermann FV, Kutish GF, Pillatzki A, Long C, Ohnstad M, Diel DG. Identification and genetic characterization of an isolate of bovine adenovirus 7 from the United States, a putative member of a new species in the genus Atadenovirus. Arch Virol. 2021 Oct;166(10):2835-2839. doi: 10.1007/s00705-021-05184-x. Epub 2021 Jul 28. PMID: 34319454.

Laverack M, Tallmadge RL, Venugopalan R, Cronk B, Zhang X, Rauh R, Saunders A, Nelson WM, Plocharczyk E, Diel DG. Clinical evaluation of a multiplex real-time RT-PCR assay for detection of SARS-CoV-2 in individual and pooled upper respiratory tract samples. Arch Virol. 2021 Sep;166(9):2551-2561. doi: 10.1007/s00705-021-05148-1. Epub 2021 Jul 14. PMID: 34259914; PMCID: PMC8278812.

Stenfeldt C, Bertram MR, Meek HC, Hartwig EJ, Smoliga GR, Niederwerder MC, Diel DG, Dee SA, Arzt J. The risk and mitigation of foot-and-mouth disease virus infection of pigs through consumption of contaminated feed. Transbound Emerg Dis. 2022 Jan;69(1):72-87. doi: 10.1111/tbed.14230. Epub 2021 Jul 27. PMID: 34237198.

Martins M, Rodrigues FS, Joshi LR, Jardim JC, Flores MM, Weiblen R, Flores EF, Diel DG. Orf virus ORFV112, ORFV117 and ORFV127 contribute to ORFV IA82 virulence in sheep. Vet Microbiol. 2021 Jun;257:109066. doi: 10.1016/j.vetmic.2021.109066. Epub 2021 Apr 10. PMID: 33866062.

Fig.3

Lubinski B, Fernandes MHV, Frazier L, Tang T, Daniel S, Diel DG, Jaimes JA, Whittaker GR. Functional evaluation of the P681H mutation on the proteolytic activation of the SARS-CoV-2 variant B.1.1.7 (Alpha) spike. iScience. 2022 Jan 21;25(1):103589. doi: 10.1016/j.isci.2021.103589. Epub 2021 Dec 10. PMID: 34909610; PMCID: PMC8662955.

Falkenberg S, Buckley A, Laverack M, Martins M, Palmer MV, Lager K, Diel DG. Experimental Inoculation of Young Calves with SARS-CoV-2. Viruses. 2021 Mar 9;13(3):441. doi: 10.3390/v13030441. PMID: 33803455; PMCID: PMC8000368.

Picture1

Palmer MV, Martins M, Falkenberg S, Buckley A, Caserta LC, Mitchell PK, Cassmann ED, Rollins A, Zylich NC, Renshaw RW, Guarino C, Wagner B, Lager K, Diel DG. Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2. J Virol. 2021 Mar 10;95(11):e00083-21. doi: 10.1128/JVI.00083-21. Epub ahead of print. PMID: 33692203; PMCID: PMC8139686.

FIG4

C Caserta L, Mitchell PK, Plocharczyk E, Diel DG. Identification of a SARS-CoV-2 Lineage B1.1.7 Virus in New York following Return Travel from the United Kingdom. Microbiol Resour Announc. 2021 Mar 4;10(9):e00097-21. doi: 10.1128/MRA.00097-21. PMID: 33664151; PMCID: PMC7936631.

Ledbetter EC, Spertus CB, Diel DG, Dubovi EJ. Intensive ocular sampling for the detection of subclinical canine herpesvirus-1 shedding in dogs with experimentally-induced latent infection. Vet Microbiol. 2021 Mar;254:109001. doi: 10.1016/j.vetmic.2021.109001. Epub 2021 Jan 27. PMID: 33540209.

Yu J, Sreenivasan C, Uprety T, Gao R, Huang C, Lee EJ, Lawson S, Nelson J, Christopher-Hennings J, Kaushik RS, Nelson E, Diel DG, Hause BM, Li F, Wang D. Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus. NPJ Vaccines. 2021 Feb 1;6(1):22. doi: 10.1038/s41541-021-00283-x. PMID: 33526776; PMCID: PMC7851141.

Niederwerder MC, Dee S, Diel DG, Stoian AMM, Constance LA, Olcha M, Petrovan V, Patterson G, Cino-Ozuna AG, Rowland RRR. Mitigating the risk of African swine fever virus in feed with anti-viral chemical additives. Transbound Emerg Dis. 2021 Mar;68(2):477-486. doi: 10.1111/tbed.13699. Epub 2020 Jul 11. PMID: 32613713.

Katwal P, Uprety T, Okda F, Antony L, Thomas M, Chase C, Diel DG, Nelson E, Young A, Li F, Scaria J, Kaushik RS. Characterization of bovine ileal epithelial cell line for lectin binding, susceptibility to enteric pathogens, and TLR mediated immune responses. Comp Immunol Microbiol Infect Dis. 2021 Feb;74:101581. doi: 10.1016/j.cimid.2020.101581. Epub 2020 Nov 17. PMID: 33260019.

2020

McAloose D, Laverack M, Wang L, Killian ML, Caserta LC, Yuan F, Mitchell PK, Queen K, Mauldin MR, Cronk BD, Bartlett SL, Sykes JM, Zec S, Stokol T, Ingerman K, Delaney MA, Fredrickson R, Ivančić M, Jenkins-Moore M, Mozingo K, Franzen K, Bergeson NH, Goodman L, Wang H, Fang Y, Olmstead C, McCann C, Thomas P, Goodrich E, Elvinger F, Smith DC, Tong S, Slavinski S, Calle PP, Terio K, Torchetti MK, Diel DG. From People to Panthera: Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo. mBio. 2020 Oct 13;11(5):e02220-20. doi: 10.1128/mBio.02220-20. PMID: 33051368; PMCID: PMC7554670.

Global_and_Zoo_Networks_Combined_7-10-2020

Wang L, Mitchell PK, Calle PP, Bartlett SL, McAloose D, Killian ML, Yuan F, Fang Y, Goodman LB, Fredrickson R, Elvinger F, Terio K, Franzen K, Stuber T, Diel DG, Torchetti MK. Complete Genome Sequence of SARS-CoV-2 in a Tiger from a U.S. Zoological Collection. Microbiol Resour Announc. 2020 May 28;9(22):e00468-20. doi: 10.1128/MRA.00468-20. PMID: 32467283; PMCID: PMC7256270.

Ebling R, Martins B, Jardim JC, Flores MM, Diel DG, Weiblen R, Flores EF. Late development of pustular, erosive lesions in the muzzle of calves inoculated with Pseudocowpox virus. Microb Pathog. 2020 Jun;143:104122. doi: 10.1016/j.micpath.2020.104122. Epub 2020 Mar 10. PMID: 32169495.

Stoian AMM, Petrovan V, Constance LA, Olcha M, Dee S, Diel DG, Sheahan MA, Rowland RRR, Patterson G, Niederwerder MC. Stability of classical swine fever virus and pseudorabies virus in animal feed ingredients exposed to transpacific shipping conditions. Transbound Emerg Dis. 2020 Jul;67(4):1623-1632. doi: 10.1111/tbed.13498. Epub 2020 Feb 9. PMID: 31999072.

Joshi LR, Mohr KA, Gava D, Kutish G, Buysse AS, Vannucci FA, Piñeyro PE, Crossley BM, Schiltz JJ, Jenkins-Moore M, Koster L, Tell R, Schaefer R, Marthaler D, Diel DG. Genetic diversity and evolution of the emerging picornavirus Senecavirus A. J Gen Virol. 2020 Feb;101(2):175-187. doi: 10.1099/jgv.0.001360. Epub 2019 Dec 20. PMID: 31859611.

Figure5_Electrostatic

2019

Sharma B, Fernandes MHV, de Lima M, Joshi LR, Lawson S, Diel DG. A Novel Live Attenuated Vaccine Candidate Protects Against Heterologous Senecavirus A Challenge. Front Immunol. 2019 Nov 26;10:2660. doi: 10.3389/fimmu.2019.02660. PMID: 31849928; PMCID: PMC6901945.

Fig 6

Gomes Noll JC, Joshi LR, do Nascimento GM, Vieira Fernandes MH, Sharma B, Furtado Flores E, Diel DG. Deletion of the thymidine kinase gene attenuates Caprine alphaherpesvirus 1 in goats. Vet Microbiol. 2019 Oct;237:108370. doi: 10.1016/j.vetmic.2019.07.022. Epub 2019 Aug 19. PMID: 31585643.

Picture1

Stoian AMM, Zimmerman J, Ji J, Hefley TJ, Dee S, Diel DG, Rowland RRR, Niederwerder MC. Half-Life of African Swine Fever Virus in Shipped Feed. Emerg Infect Dis. 2019 Dec;25(12):2261-2263. doi: 10.3201/eid2512.191002. Epub 2019 Dec 17. PMID: 31524583; PMCID: PMC6874236.

Pandey K, Zhong S, Diel DG, Hou Y, Wang Q, Nelson E, Wang X. GTPase-activating protein-binding protein 1 (G3BP1) plays an antiviral role against porcine epidemic diarrhea virus. Vet Microbiol. 2019 Sep;236:108392. doi: 10.1016/j.vetmic.2019.108392. Epub 2019 Aug 19. PMID: 31500725; PMCID: PMC7117524.

Maggioli MF, Fernandes MHV, Joshi LR, Sharma B, Tweet MM, Noll JCG, Bauermann FV, Diel DG. Persistent Infection and Transmission of Senecavirus A from Carrier Sows to Contact Piglets. J Virol. 2019 Oct 15;93(21):e00819-19. doi: 10.1128/JVI.00819-19. PMID: 31434730; PMCID: PMC6803263.

Figure8

Martins B, Ebling RC, Martins M, Diel DG, Weiblen R, Flores EF. Antigenic relationships between Caprine alphaherpesvirus 1 (CpHV-1) and Bovine alphaherpesvirus 1 (BoHV-1) and experimental CpHV-1 infection of kids and calves. Microb Pathog. 2019 Nov;136:103663. doi: 10.1016/j.micpath.2019.103663. Epub 2019 Aug 9. PMID: 31404631.

Dimitrov KM, Abolnik C, Afonso CL, Albina E, Bahl J, Berg M, Briand FX, Brown IH, Choi KS, Chvala I, Diel DG, Durr PA, Ferreira HL, Fusaro A, Gil P, Goujgoulova GV, Grund C, Hicks JT, Joannis TM, Torchetti MK, Kolosov S, Lambrecht B, Lewis NS, Liu H, Liu H, McCullough S, Miller PJ, Monne I, Muller CP, Munir M, Reischak D, Sabra M, Samal SK, Servan de Almeida R, Shittu I, Snoeck CJ, Suarez DL, Van Borm S, Wang Z, Wong FYK. Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus. Infect Genet Evol. 2019 Oct;74:103917. doi: 10.1016/j.meegid.2019.103917. Epub 2019 Jun 11. PMID: 31200111; PMCID: PMC6876278.

Bauermann FV, Hause B, Buysse AR, Joshi LR, Diel DG. Identification and genetic characterization of a porcine hepe-astrovirus (bastrovirus) in the United States. Arch Virol. 2019 Sep;164(9):2321-2326. doi: 10.1007/s00705-019-04313-x. Epub 2019 Jun 7. PMID: 31175435.

Fernandes MHV, Maggioli MF, Otta J, Joshi LR, Lawson S, Diel DG. Senecavirus A 3C Protease Mediates Host Cell Apoptosis Late in Infection. Front Immunol. 2019 Mar 13;10:363. doi: 10.3389/fimmu.2019.00363. PMID: 30918505; PMCID: PMC6424860.

image description

Ramírez M, Bauermann FV, Navarro D, Rojas M, Manchego A, Nelson EA, Diel DG, Rivera H. Detection of porcine reproductive and respiratory syndrome virus (PRRSV) 1-7-4-type strains in Peru. Transbound Emerg Dis. 2019 May;66(3):1107-1113. doi: 10.1111/tbed.13134. Epub 2019 Mar 2. PMID: 30688036.

Joshi LR, Bauermann FV, Hain KS, Kutish GF, Armién AG, Lehman CP, Neiger R, Afonso CL, Tripathy DN, Diel DG. Detection of Fowlpox virus carrying distinct genome segments of Reticuloendotheliosis virus. Virus Res. 2019 Jan 15;260:53-59. doi: 10.1016/j.virusres.2018.10.017. Epub 2018 Oct 22. PMID: 30359622.