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Understanding the interplay between viruses, host cells and the host immune system is critical for the development of improved vaccines, vaccine vectors, or therapeutic agents for viral disease prevention and control.

This is an essential biological problem, in that it implies understanding the interplay between virus-encoded proteins and the host responses to infection. However, it represents a fundamental challenge as viruses have developed sophisticated mechanisms to manipulate the host cell machinery and enhance production of progeny virus, or to evade the host immune responses and ensure virus infection and successful replication.

The focus of our research has been on: 1) basic and molecular mechanisms of virus-host interactions and the associated impacts of such interactions on the severity and outcome of disease, and 2)  the development of novel viral vectors and vaccines for infectious disease prevention and control.